L. Lai

Transcriptome-wide identification of 5-methylcytosine by deaminase and reader protein-assisted sequencing

This paper introduces DRAM, a method for transcriptome-wide m5C detection using deaminase and reader proteins, showing high overlap with BS-seq data and supporting low-input RNA.

A Combination of Machine Learning and PBPK Modeling Approach for Pharmacokinetics Prediction of Small Molecules in Humans

This paper combines machine learning and PBPK modeling to predict small molecule pharmacokinetics in humans without experimental data, achieving higher accuracy than traditional methods.

Immunogenicity and protective efficacy of an influenza virus-like particle-based SARS-CoV-2 hybrid vaccine candidate in rhesus macaques

This study evaluates a hybrid vaccine combining influenza and SARS-CoV-2 antigens in rhesus macaques, showing strong immune responses and protection against SARS-CoV-2 infection.

Sodium-glucose co-transporter 2 Inhibitors Act Independently of SGLT2 to Confer Benefit for Heart Failure with Reduced Ejection Fraction in Mice

This study shows that SGLT2 inhibitors improve heart failure in mice independently of their metabolic effects, even when SGLT2 is absent.

All-atom protein sequence design based on geometric deep learning

This paper introduces GeoSeqBuilder, a geometric deep learning framework for protein sequence design that achieves high accuracy in recovering native residues and predicting side-chain conformations.

XBB.1.5 monovalent booster improves antibody binding and neutralization against emerging SARS-CoV-2 Omicron variants

The paper evaluates the effectiveness of an XBB.1.5 monovalent booster vaccine, showing improved antibody binding and neutralization against SARS-CoV-2 Omicron variants.

The change of lymphocyte subsets and inflammatory cytokine in BK viruria

This study compares cytokine levels in urine and blood of kidney transplant recipients with and without BK viruria, finding higher inflammatory cytokines in BK-positive patients.

Two subtypes of GTPase-activating proteins coordinate tip growth and cell size regulation in Physcomitrium patens

This study identifies two subtypes of GTPase-activating proteins that regulate tip growth and cell size in moss by modulating ROP activity and membrane organization.

Expansion of Disease Specific Cardiac Macrophages in Immune Checkpoint Inhibitor Myocarditis

This study identifies an inflammatory macrophage population expanded in ICI myocarditis, driven by IFN-γ signaling and T-cell interactions, suggesting IFN-γ blockade as a potential therapeutic strategy.

MORE IS DIFFERENT: DRUG PROPERTY ANALYSIS ON CELLULAR HIGH-CONTENT IMAGES USING DEEP LEARNING

The paper introduces MID, a deep learning method for high-content image analysis that outperforms existing tools in drug toxicity classification and compound identification.

mRNA bivalent booster enhances neutralization against BA.2.75.2 and BQ.1.1

This study evaluates the neutralizing efficacy of bivalent mRNA boosters against emerging SARS-CoV-2 subvariants BA.2.75.2 and BQ.1.1, showing improved protection compared to monovalent boosters.

Molecular basis of SARS-CoV-2 Omicron variant evasion from shared neutralizing antibody response

The paper identifies three monoclonal antibodies that poorly neutralize the Omicron BA.1 variant, revealing structural and molecular features of antibody evasion.

Hypoxia Sensing in Resident Cardiac Macrophages Regulates Monocyte Fate Specification following Ischemic Heart Injury

This study shows that hypoxia sensing in cardiac macrophages influences monocyte differentiation into inflammatory states after heart injury.

Coevolution-based prediction of key allosteric residues for protein function regulation

This paper introduces KeyAlloSite, a method to predict key allosteric residues using coevolutionary coupling, showing its accuracy in known proteins and applications in drug design and enzyme engineering.

Structural insights for neutralization of BA.1 and BA.2 Omicron variants by a broadly neutralizing SARS-CoV-2 antibody

This paper identifies and structurally analyzes an antibody that neutralizes SARS-CoV-2 BA.1 and BA.2 variants, revealing its unique epitope and mechanism of action.

Human papilloma virus E6 regulates therapy responses in oropharyngeal cancer by repressing the PGC-1α/ERRα axis

This study shows that HPV E6 reduces mitochondrial antioxidant capacity and therapy resistance in oropharyngeal cancer by suppressing the PGC-1α/ERRα pathway.

Compartmentalization and persistence of dominant (regulatory) T cell clones indicates antigen skewing in juvenile idiopathic arthritis

The paper identifies persistent, antigen-specific T cell clones in JIA joints and circulation, suggesting antigen-driven expansion of both Tregs and Teffector cells.

Generating Functional Cells Through Enhanced Interspecies Chimerism with Human Pluripotent Stem Cells

This study demonstrates that MYCN and BCL2 enhance interspecies chimerism with human pluripotent stem cells, enabling the generation of functional human blood progenitor cells in chimeric embryos.

Influenza virus-like particle-based hybrid vaccine containing RBD induces immunity against influenza and SARS-CoV-2 viruses

This study develops a hybrid vaccine combining influenza VLPs with SARS-CoV-2 RBD and GM-CSF, showing protection against both viruses in mice.

mRNA-1273 and BNT162b2 mRNA vaccines have reduced neutralizing activity against the SARS-CoV-2 Omicron variant

This study evaluates the neutralizing activity of mRNA vaccines against the SARS-CoV-2 Omicron variant, showing reduced efficacy after the second dose but improved responses following a third dose.

Structural insights into the mechanism of nucleotide regulation of pancreatic KATP channel

This study presents cryo-EM structures of pancreatic KATP channels in closed and pre-open states, revealing nucleotide binding mechanisms and activation by Mg-ADP and diazoxide-type openers.

Protection against SARS-CoV-2 Beta Variant in mRNA-1273 Boosted Nonhuman Primates

mRNA-1273 boosted nonhuman primates show increased neutralizing antibody responses and protection against SARS-CoV-2 beta variant infection.

Longitudinal immune dynamics of mild COVID-19 define signatures of recovery and persistence

The paper profiles longitudinal immune responses in mild COVID-19 patients to identify recovery and persistence signatures.

Evaluation of mRNA-1273 against SARS-CoV-2 B.1.351 Infection in Nonhuman Primates

This study evaluates mRNA-1273 vaccine efficacy against SARS-CoV-2 B.1.351 in nonhuman primates, finding that two doses significantly reduce viral replication in the airways.

Durability of mRNA-1273-induced antibodies against SARS-CoV-2 variants

This study assesses the durability of mRNA-1273-induced antibodies against SARS-CoV-2 variants over seven months, finding persistent but reduced binding and functional responses.

Infection and vaccine-induced neutralizing antibody responses to the SARS-CoV-2 B.1.617.1 variant

This study assesses neutralizing antibody responses to the SARS-CoV-2 B.1.617.1 variant in convalescent and vaccinated individuals, finding it is 6.8-fold more resistant but still neutralizable.

Immune Correlates of Protection by mRNA-1273 Immunization against SARS-CoV-2 Infection in Nonhuman Primates

This study shows that mRNA-1273 vaccine-induced antibody responses correlate with protection against SARS-CoV-2 infection in nonhuman primates.

Vaccination with SARS-CoV-2 Spike Protein and AS03 Adjuvant Induces Rapid Anamnestic Antibodies in the Lung and Protects Against Virus Challenge in Nonhuman Primates

This study shows that an AS03-adjuvanted SARS-CoV-2 spike protein vaccine induces strong antibody responses and protects nonhuman primates from viral challenge.

Reduced binding and neutralization of infection- and vaccine-induced antibodies to the B.1.351 (South African) SARS-CoV-2 variant

The paper compares antibody binding and neutralization against SARS-CoV-2 B.1 and B.1.351 variants in infected and vaccinated individuals, finding reduced titers but retained neutralization.

Adjuvanting a subunit SARS-CoV-2 nanoparticle vaccine to induce protective immunity in non-human primates

This study evaluates adjuvants for a subunit SARS-CoV-2 nanoparticle vaccine in non-human primates, showing durable neutralizing antibody responses and protection against infection.