PIEZO1 force sensing controls global lipid homeostasis
L. Lichtenstein, C. W. Cheng, E. L. Evans, H. J. Gaunt, F. Bartoli, E. Chuntharpursat-Bon, S. Patel, C. Konstantinou, S. Futers, M. Reay, G. Parsonage, J. Bertrand-Michel, P. Sukumar, L. D. Roberts, D. J. Beech
This study shows that endothelial PIEZO1 force sensing regulates lipid homeostasis by affecting cholesterol metabolism and excretion, with implications for hyperlipidaemia.
bioRxiv · Jul 23, 2023 · PreprintPhysiology