Author

F. Berst

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 3 Research Focus:drug response / drug discovery· 3 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

F. J. Zecri· 3 shared J. W. Mason· 3 shared K. Briner· 3 shared S. Bonazzi· 3 shared S. L. Schreiber· 3 shared A. Tutter· 2 shared B. K. Hua· 2 shared C. W. Coley· 2 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersBiophysics

F. J. Zecri

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3 papers

Recent·Most cited

Rational screening for cooperativity in small-molecule inducers of protein-protein associations

S. Liu, B. Tong, J. W. Mason, J. M. Ostrem, A. Tutter, B. K. Hua, S. A. Tang, S. Bonazzi, K. Briner, F. Berst, F. J. Zecri, S. L. Schreiber

The paper introduces a binding-based screen to identify cooperative small-molecule inducers of protein-protein interactions, identifying a compound with high cooperativity comparable to classical molecular glues.

bioRxiv · May 22, 2023Biophysics

Diversity-oriented synthesis encoded by deoxyoligonucleotides

L. Hudson, J. W. Mason, M. V. Westphal, M. J. R. Richter, J. R. Thielman, B. K. Hua, C. J. Gerry, G. Xia, H. L. Osswald, J. M. Knapp, Z. Y. Tan, P. Kokkonda, B. I. C. Tresco, S. Liu, A. G. Reidenbach, , K. Briner

The paper describes the design, synthesis, and validation of a 3.7 million-member DNA-encoded library using diversity-oriented synthesis to enhance structural diversity for drug discovery.

bioRxiv · Oct 16, 2022Biochemistry

DNA-encoded library (DEL)-enabled discovery of proximity-inducing small molecules

J. W. Mason, L. Hudson, M. V. Westphal, A. Tutter, G. Michaud, W. Shu, X. Ma, C. W. Coley, P. A. Clemons, S. Bonazzi, F. Berst, F. J. Zecri, K. Briner, S. L. Schreiber

This paper uses DNA-encoded libraries to discover small molecules that induce protein-protein associations between BRD4 and VHL-elongin C-elongin B.

bioRxiv · Oct 13, 2022Pharmacology & Toxicology