BiophysicsbioRxiv
Rational screening for cooperativity in small-molecule inducers of protein-protein associations
S. Liu, B. Tong, J. W. Mason…·S. L. Schreiber
The paper introduces a binding-based screen to identify cooperative small-molecule inducers of protein-protein interactions, identifying a compound with high cooperativity comparable to classical molecular glues.
DOI 10.1021/jacs.3c08307