Noninvasive cancer detection by extracting and integrating multi-modal data from whole-methylome sequencing of plasma cell-free DNA
F. Bie, Z. Wang, Y. Li, Y. Hong, T. Han, F. Lv, S. Yang, S. Li, X. Li, P. Nie, R. Zang, M. Zhang, P. Song, F. Feng, W. Guo, , S. Gao
This paper develops a method to detect cancer noninvasively by integrating methylation, fragmentation, and copy number data from plasma cell-free DNA using machine learning.
bioRxiv · Jul 4, 2022 · PreprintCancer Biology