Author

F. Chan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Research Focus:development & morphogenesis· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Assay:imaging· 1 Organism:mouse· 1 Research Focus:protein design· 1

Frequent Co-Authors

A. Bera· 1 shared A. Courbet· 1 shared A. Kang· 1 shared B. I. M. Wicky· 1 shared B. Koepnick· 1 shared B. Sankaran· 1 shared C. Deutsch· 1 shared C. Park· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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1 shared paperBiophysics

A. Bera

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Robust deep learning based protein sequence design using ProteinMPNN

J. Dauparas, I. Anishchenko, N. Bennett, H. Bai, R. J. Ragotte, L. F. Milles, B. I. M. Wicky, A. Courbet, R. J. de Haas, N. Bethel, P. J. Y. Leung, T. F. Huddy, S. Pellock, D. Tischer, F. Chan, , D. Baker

A deep learning method for protein sequence design shows high performance in both simulations and experiments, applicable to various design challenges.

bioRxiv · Jun 3, 2022Biophysics

Biochemical Barriers on the Path to Ocean Anoxia?

S. J. Giovannoni, F. Chan, E. W. Davis, C. Deutsch, S. S. Wolf

The paper proposes the Hypoxic Barrier Hypothesis to explain why ocean oxygen levels remain higher than expected despite microbial respiration, finding a large variation in oxygen affinity among enzymes.

bioRxiv · May 17, 2021Microbiology

The scaffold-dependent function of RIPK1 in dendritic cells promotes injury-induced colitis

K. Moriwaki, C. Park, K. Koyama, S. Balaji, K. Kita, R. Yagi, S. Komazawa-Sakon, T. Asuka, H. Nakano, Y. Kamada, E. Miyoshi, F. Chan

This study shows that RIPK1's scaffold function in dendritic cells prevents colonic inflammation and maintains immune homeostasis by inhibiting apoptosis and necroptosis.

bioRxiv · Feb 27, 2021Immunology