Cryo-EM confirms a common fibril fold in the heart of four patients with ATTRwt amyloidosis
B. A. Nguyen, V. Singh, S. Afrin, P. Singh, M. Pekala, Y. Ahmed, R. Pedretti, J. Canepa, A. Lemoff, B. Kluve-Beckerman, P. Wydorski, F. Chhapra, L. Saelices
The paper uses cryo-EM to show that cardiac ATTRwt amyloid fibrils from four patients are structurally identical, supporting their consistent clinical presentation.
bioRxiv · Mar 8, 2024Biophysics