Author

S. Afrin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Microbiology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Assay:cryo-EM· 2 Research Focus:protein structure prediction· 2 Organism:bacteria (other)· 1 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

B. A. Nguyen· 3 shared P. Singh· 3 shared R. Pedretti· 3 shared V. Singh· 3 shared A. Lemoff· 2 shared B. Kluve-Beckerman· 2 shared L. Saelices· 2 shared M. Pekala· 2 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersBiophysics

B. A. Nguyen

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

ATTRv-V30M Type A amyloid fibrils from the heart and nerves exhibit structural homogeneity.

B. A. Nguyen, S. Afrin, A. Yakubovska, V. Singh, J. Vaquer-Alicea, P. Kunach, P. Singh, M. Pekala, Y. Ahmed, M. d. C. Fernandez-Ramirez, L. Cabrera Hernandez, R. Pedretti, P. Bassett, L. Wang, A. Lemoff, , L. Saelices Gomez

This study determines the structure of ATTRv-V30M amyloid fibrils from cardiac and nerve tissues using cryo-EM, finding structural homogeneity across tissues when transthyretin originates from the liver.

bioRxiv · May 14, 2024 · PreprintBiophysics

Cryo-EM confirms a common fibril fold in the heart of four patients with ATTRwt amyloidosis

B. A. Nguyen, V. Singh, S. Afrin, P. Singh, M. Pekala, Y. Ahmed, R. Pedretti, J. Canepa, A. Lemoff, B. Kluve-Beckerman, P. Wydorski, F. Chhapra, L. Saelices

The paper uses cryo-EM to show that cardiac ATTRwt amyloid fibrils from four patients are structurally identical, supporting their consistent clinical presentation.

bioRxiv · Mar 8, 2024Biophysics

O-GlcNAc modification forces the formation of an α-Synuclein amyloid-strain with notably diminished seeding activity and pathology

A. T. Balana, A.-L. Mahul-Mellier, B. A. Nguyen, M. Horvath, A. Javed, E. R. Hard, Y. Jasiqi, P. Singh, S. Afrin, R. Pedretti, V. Singh, V. M.-Y. Lee, K. C. Luk, L. Saelices, H. A. Lashuel, M. R. Pratt

This study shows that O-GlcNAc modification of α-Synuclein leads to amyloid fibrils with reduced seeding activity and pathology in Parkinson's disease models.

bioRxiv · Mar 7, 2023 · PreprintBiochemistry

Contribution of noncanonical antigens to virulence and adaptive immunity in human infection with enterotoxigenic E. coli

F. M. Kuhlmann, R. O. Laine, S. Afrin, R. Nakajima, M. Akhtar, T. J. Vickers, K. Parker, N. Nizam, V. Grigura, C. W. Goss, P. L. Felgner, D. Rasko, F. Qadri, J. M. Fleckenstein

The paper identifies noncanonical antigens, EtpA and EatA, associated with ETEC virulence and immune response, suggesting their potential inclusion in vaccine design.

bioRxiv · Oct 20, 2020Microbiology

Antagonistic activity of Bacillus amyloliquefaciens subsp. amyloliquefaciens against multidrug resistant Serratia rubidaea

M. N. I. Bhuiyan, S. Afrin

This study identifies a Bacillus amyloliquefaciens isolate from soil that inhibits Serratia rubidaea and other pathogens, showing stability under various environmental conditions.

bioRxiv · Oct 24, 2019 · PreprintMicrobiology