F. Demir

Bioengineering secreted proteases converts divergent Rcr3 orthologs and paralogs into extracellular immune co-receptors

This study bioengineers proteases to convert Rcr3 orthologs and Pip1 into immune co-receptors that trigger Avr2/Cf-2 dependent immunity in tomato.

Phytocystatin 6 is a context-dependent, tight-binding inhibitor of Arabidopsis thaliana legumain isoform β

The paper identifies AtCYT6 as a tight-binding inhibitor of AtLEGβ in Arabidopsis, revealing its dual inhibition mechanism and context-dependent regulation.

A phloem-localized Arabidopsis metacaspase (AtMC3) improves drought tolerance

This study shows that overexpressing AtMC3, a phloem-specific metacaspase in Arabidopsis, improves drought tolerance by enhancing vascular function and osmotic stress responses.

Epichloe festucae in mutualistic association with Lolium perenne suppresses host apoplastic cysteine protease activity

This study identifies and characterizes apoplastic cysteine proteases in Lolium perenne and shows that mutualistic Epichloe festucae suppresses their activity through potential inhibitors like LpCys1.

Sensitive determination of proteolytic proteoforms in limited microscale proteome samples

The paper introduces a method for identifying thousands of N-termini from small samples, demonstrating its application across various biological contexts.