J. Tsui

Commensal myeloid crosstalk in neonatal skin regulates cutaneous type 17 inflammation

This study shows that commensal microbes in neonatal skin promote immune homeostasis by regulating monocyte accumulation and IL-17A production by T cells.

Synchrony of Bird Migration with Avian Influenza Global Spread; Implications for Vulnerable Bird Orders

The paper uses phylodynamic analyses to link bird migration patterns with the global spread of HPAIV H5 clade 2.3.4.4, identifying vulnerable bird orders and highlighting Suliformes and Ciconiiformes as important in virus dispersal.

Inducing an oxidized redox-balance improves anti-tumor CD8+ T cell function

This study shows that inducing an oxidized redox balance in CD8+ T cells enhances their anti-tumor function in vivo through increased mitochondrial ROS.

Single-cell and spatial multi-omics highlight effects of anti-integrin therapy across cellular compartments in ulcerative colitis

This study uses single-cell and spatial multi-omics to show VDZ affects mononuclear phagocyte subsets and highlights gene expression patterns in UC.

Multi-omic profiling of the leukemic microenvironment shows bone marrow interstitial fluid is distinct from peripheral blood plasma

This study compares bone marrow interstitial fluid and peripheral blood plasma in pediatric acute lymphoblastic leukemia, finding distinct metabolic, lipid, and protein profiles before and after chemotherapy.

Holistic Characterization of Tumor Monocyte-to-Macrophage Differentiation Integrates Distinct Immune Phenotypes in Kidney Cancer

This study characterizes monocyte-to-macrophage differentiation in kidney cancer using scRNA-seq, linking immune phenotypes to T cell function and patient outcomes.

Multiomic Characterization of Stage I Lung Adenocarcinoma Reveals Distinct Genetic and Immunologic Features of Recurrent Disease

This study identifies distinct genetic and immunologic features of recurrent stage I lung adenocarcinoma using multiomic profiling and single-cell RNA-seq.

Effective Computational Framework for Pre-Interventional Planning of Peripheral Arteriovenous Malformations with In Vivo and In Vitro Validation

This paper develops a computational framework to simulate AVM haemodynamics and predict embolisation outcomes, validated with clinical and experimental data.

A Pan-Cancer Census of Dominant Tumor Immune Archetypes

The paper identifies dominant immune system archetypes across 364 tumors from 12 cancer types using flow cytometry and transcriptomic data, linking them to tumor biology classifications.

Global Absence and Targeting of Protective Immune States in Severe COVID-19.

The paper identifies that severe COVID-19 patients lack ISG-expressing cells and have antibodies that block their production, contrasting with mild cases.

SCENITH: A flow cytometry based method to functionally profile energy metabolism with single cell resolution

SCENITH functionally profiles energy metabolism at single-cell resolution using flow cytometry, revealing variable metabolic profiles in tumor myeloid cells not linked to lineage or activation phenotype.

Sensitive determination of proteolytic proteoforms in limited microscale proteome samples

The paper introduces a method for identifying thousands of N-termini from small samples, demonstrating its application across various biological contexts.