Author

P. F. Lange

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cell Biology· 3 Biochemistry· 2 Cancer Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Assay:proteomics· 7 Research Focus:cell type annotation· 6 Approach:experimental assay· 6 Research Focus:differential expression· 5 Organism:human· 5 Organism:mouse· 3 Research Focus:protein folding & dynamics· 3 Approach:statistical model· 3

Frequent Co-Authors

L. Nierves· 5 shared J. Tsui· 3 shared A. C. Uzozie· 2 shared A. Karsan· 2 shared E. K. Ergin· 2 shared G. Cole· 2 shared J. Gsponer· 2 shared J. Wang· 2 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

5 shared papersCancer Biology

L. Nierves

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Analysis of protein levels and solubility in distinct brain regions reveals several elements of the protein homeostasis network that are impacted by aging

C. Molzahn, E. Kuechler, L. Nierves, G. Cole, J. Wang, N. Cashman, A. Karsan, P. F. Lange, J. Gsponer, T. Mayor

The paper analyzes protein levels and solubility in brain regions of aged mice, revealing age-related changes in proteostasis and inflammation markers.

bioRxiv · Feb 28, 2024 · PreprintCell Biology

Mechanisms of Pathogenicity of Hypertrophic Cardiomyopathy-Associated Troponin T (TNNT2) Variant R278C+/- During Development

S. Shafaattalab, A. Y. LI, Y. Maaref, F. Jayousi, S. Dababneh, H. Hamledari, D. H. Baygi, T. Barszczewski, B. Rupai, S. Jannati, R. Nagalingam, A. M. Cool, P. Langa, M. Chiao, T. Roston, , G. F. Tibbits

This study investigates the pathogenic mechanisms of the TNNT2 R278C+/- variant in cardiomyocytes using proteomics and functional assays, revealing its impact on cardiac function and arrhythmia.

bioRxiv · Jun 6, 2023 · PreprintCell Biology

Inducing an oxidized redox-balance improves anti-tumor CD8+ T cell function

J. H. Oh, R. A. Cederberg, L. Bopp, E. Tanaka, T. Ser, S. Niyyati, A. E. Patterson, N. Amanat, J. Dutra, P. Ye, M. Clark, K. Ward-Hartstonge, A.-S. Archambault, J. Tsui, P. F. Lange, , R. I. K. Geltink

This study shows that inducing an oxidized redox balance in CD8+ T cells enhances their anti-tumor function in vivo through increased mitochondrial ROS.

bioRxiv · Mar 27, 2023 · PreprintImmunology

Shift of the insoluble content of the proteome in aging mouse brain

C. M. Molzahn, E. R. Kuechler, I. Zemlyankina, L. Nieves, T. Ali, G. Cole, J. Wang, R. F. Albu, M. Zhu, N. Cashman, S. Gilch, A. Karsan, P. F. Lange, J. Gsponer, T. Mayor

This study identifies age-related changes in the insoluble proteome of mouse brains, showing a shift in protein characteristics associated with proteostasis decline.

bioRxiv · Dec 13, 2022Cell Biology

Multi-omic profiling of the leukemic microenvironment shows bone marrow interstitial fluid is distinct from peripheral blood plasma

L. Nierves, J. Guo, S. Chen, J. Tsui, A. C. Uzozie, J. W. Bush, T. Huan, P. F. Lange

This study compares bone marrow interstitial fluid and peripheral blood plasma in pediatric acute lymphoblastic leukemia, finding distinct metabolic, lipid, and protein profiles before and after chemotherapy.

bioRxiv · Mar 30, 2022Cancer Biology

Detectability of biotin tags by LC-MS/MS

L. Nierves, P. F. Lange

The paper compares two biotin labels to assess their impact on peptide detection by LC-MS/MS, finding that biotinylation increases hydrophobicity and reduces charge, requiring gradient optimization and inclusion of singly charged precursors.

bioRxiv · Dec 30, 2020Biochemistry

PDX models reflect the proteome landscape of pediatric acute lymphoblastic leukemia but divert in select pathways

A. C. Uzozie, E. K. Ergin, N. Rolf, A. Lorentzian, S. S. Weng, L. Nierves, T. G. Smith, C. J. Lim, C. A. Maxwell, G. S. Reid, P. F. Lange

This study compares proteome and post-translational modification landscapes between pediatric leukemia patients and their xenograft models, finding both similarities and key divergences.

bioRxiv · Dec 18, 2019Cancer Biology

Sensitive determination of proteolytic proteoforms in limited microscale proteome samples

S. S. H. Weng, F. Demir, E. K. Ergin, S. Dirnberger, A. Uzozie, D. Tuscher, L. Nierves, J. Tsui, P. F. Huesgen, P. F. Lange

The paper introduces a method for identifying thousands of N-termini from small samples, demonstrating its application across various biological contexts.

bioRxiv · Mar 3, 2019Biochemistry