BiochemistrybioRxiv
THE RIBOREGULATION MECHANISM OF HUMAN SERINE HYDROXYMETHYLTRANSFERASE IS ROOTED IN AN ALLOSTERIC SWITCH
S. Spizzichino, F. Di Fonzo, C. Marabelli…·F. Cutruzzola
This study identifies an allosteric RNA switch mechanism regulating SHMT1 activity, revealing structural elements critical for RNA binding and implications for RNA-based therapies.
DOI 10.1016/j.molcel.2024.06.016