A. J. Jakobi

This study determines the cryo-EM structure of human GBP1 dimer and coatomer assemblies, revealing how nucleotide binding and hydrolysis drive membrane targeting and coatomer formation.

This study identifies an allosteric RNA switch mechanism regulating SHMT1 activity, revealing structural elements critical for RNA binding and implications for RNA-based therapies.

The paper uses particle fusion of single molecule localization microscopy data to determine the dimer structure of Nup96 in the Nuclear Pore Complex, showing 32 copies per pore.

The paper determines the cryo-EM structure of gas vesicles from B. megaterium, revealing their self-assembly mechanism and structural features that enable buoyancy control.

The paper shows that multivalent interactions enable motor-dependent protein accumulation at microtubule ends through disordered networks and liquid droplet formation in a reconstituted fission yeast system.

This paper introduces nanofluidic chips for cryo-EM that enable reproducible ice thickness from picoliter samples, improving high-resolution structure determination.

The paper introduces an iterative method to improve cryo-EM density maps using an atomic reference, leading to better atomic models.