Author

F. Finotello

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:drug response / drug discovery· 3 Assay:bulk RNA-seq· 2 Approach:deep learning· 2 Research Focus:differential expression· 2 Approach:statistical model· 2 Approach:benchmark study· 1 Approach:biophysical modeling· 1

Frequent Co-Authors

F. Eduati· 2 shared O. Lapuente-Santana· 2 shared A. D. Garg· 1 shared A. D. Sahu· 1 shared A. Martowicz· 1 shared A. Pircher· 1 shared A. S. Halkola· 1 shared B. G. Vincent· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersCancer Biology

F. Eduati

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Author profile →

4 papers

Recent·Most cited

A Community Challenge to Predict Clinical Outcomes After Immune Checkpoint Blockade in Non-Small Cell Lung Cancer

M. Mason, O. Lapuente-Santana, A. S. Halkola, W. Wang, R. Mall, X. Xiao, J. Kaufman, J. Fu, J. Pfeil, J. Banerjee, V. Chung, H. Chang, S. D. Chasalow, H. Y. Lin, R. Chai, , B. G. Vincent

The paper evaluates predictive models for immune checkpoint inhibitor outcomes in NSCLC using clinical trial data from two RCTs, finding that models combining PD-L1, TMB, and immune signatures outperform single biomarkers.

Journal of Translational Medicine · Feb 21, 2024Peer-reviewedCancer Biology

High-resolution single-cell atlas reveals diversity and plasticity of tissue-resident neutrophils in non-small cell lung cancer

S. Salcher, G. Sturm, L. Horvath, G. Untergasser, G. Fotakis, E. Panizzolo, A. Martowicz, G. Pall, G. Gamerith, M. Sykora, F. Augustin, K. Schmitz, F. Finotello, D. Rieder, S. Sopper, , Z. Trajanoski

The paper integrates single-cell data to create a high-resolution atlas of NSCLC tumor microenvironments, revealing immune cell diversity, neutrophil plasticity, and associations with treatment outcomes.

bioRxiv · May 9, 2022Cancer Biology

Predictive systems biomarkers of response to immune checkpoint inhibitors

O. Lapuente-Santana, M. van Genderen, P. Hilbers, F. Finotello, F. Eduati

This study develops EaSIeR, a method using RNA-seq data and prior knowledge to predict immune response to PD-1 inhibitors by analyzing tumor microenvironment signatures.

bioRxiv · Feb 5, 2021Cancer Biology

The IRE1 Inhibitor KIRA6 Curtails The Inflammatory Trait Of Immunogenic Anticancer Treatments By Targeting HSP60 Independent Of IRE1

N. Rufo, D. Korovesis, S. van Eygen, R. Derua, A. D. Garg, F. Finotello, M. Vara Perez, J. Rozanc, M. Dewaele, P. A. de Witte, L. Alexopoulos, S. Janssens, L. Sinkkonen, T. Sauter, S. H. L. Verhelst, P. Agostinis

The paper shows KIRA6 reduces inflammation from immunogenic cancer treatments by targeting HSP60, not through IRE1 inhibition.

bioRxiv · Dec 24, 2020 · PreprintCancer Biology