ImmunologybioRxivPreprint
High-resolution profiling of neoantigen-specific T cell receptor activation signatures links moderate stimulation patterns to resilience and sustained tumor control
F. Füchsl, J. Untch, V. Kavaka…·A. M. Krackhardt
The paper identifies and characterizes neoantigen-specific T cell receptors (neoTCRs) using single-cell sequencing and in vitro/in vivo experiments, finding that moderate activation profiles enhance tumor control.