Author

J. Untch

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Approach:experimental assay· 1 Assay:proteomics· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

A. M. Krackhardt· 2 shared R. Rad· 2 shared B. Haller· 1 shared B. Klink· 1 shared B. Kuster· 1 shared C. Tretter· 1 shared C. Vogelsang· 1 shared C. von Frankenberg· 1 shared

Activity by Year

2022-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersImmunology

A. M. Krackhardt

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2 papers

Recent·Most cited

High-resolution profiling of neoantigen-specific T cell receptor activation signatures links moderate stimulation patterns to resilience and sustained tumor control

F. Füchsl, J. Untch, V. Kavaka, S. Jarosch, C. Vogelsang, N. de Andrade Krätzig, D. Gosmann, R. Rad, D. H. Busch, E. Beltran, E. Bräunlein, A. M. Krackhardt

The paper identifies and characterizes neoantigen-specific T cell receptors (neoTCRs) using single-cell sequencing and in vitro/in vivo experiments, finding that moderate activation profiles enhance tumor control.

bioRxiv · Sep 23, 2022 · PreprintImmunology

Proteogenomic analysis reveals RNA as an important source for tumor-agnostic neoantigen identification correlating with T-cell infiltration

C. Tretter, N. de Andrade Kraetzig, M. Pecoraro, S. Lange, P. Seifert, C. von Frankenberg, J. Untch, F. S. Dreyer, E. Braeunlein, M. Wilhelm, D. P. Zolg, T. Engleitner, S. Uhrig, M. Boxberg, K. Steiger, , A. M. Krackhardt

This study identifies RNA as a significant source of tumor-agnostic neoantigens, which correlate with T-cell infiltration in multiple cancer types.

bioRxiv · Sep 17, 2022Cancer Biology