D. Gosmann

High-resolution profiling of neoantigen-specific T cell receptor activation signatures links moderate stimulation patterns to resilience and sustained tumor control

The paper identifies and characterizes neoantigen-specific T cell receptors (neoTCRs) using single-cell sequencing and in vitro/in vivo experiments, finding that moderate activation profiles enhance tumor control.

Spatial and temporal plasticity of neoantigen-specific T-cell responses bases on characteristics associated to antigen and TCR

The paper characterizes neoantigen-specific T-cell receptors in a melanoma patient, showing that low-avidity TCRs can provide effective anti-tumor responses and persist long-term in blood and tissues.