Spatial and temporal plasticity of neoantigen-specific T-cell responses bases on characteristics associated to antigen and TCR
E. Braeunlein, G. Lupoli, E. T. Abalrous, N. de Andrade Kraetzig, D. Gosmann, F. Fuechsl, L. Wietbrock, S. Lange, T. Engleitner, H. Lan, S. Audehm, M. Effenberger, M. Boxberg, K. Steiger, Y. Chang, , A. M. Krackhardt
The paper characterizes neoantigen-specific T-cell receptors in a melanoma patient, showing that low-avidity TCRs can provide effective anti-tumor responses and persist long-term in blood and tissues.
bioRxiv · Feb 2, 2021 · PreprintImmunology