H. Lan

FLASH Irradiation Regulates IFN-β induction by mtDNA via Cytochrome c Leakage

This study shows FLASH irradiation increases cytochrome c leakage from mitochondria in normal cells, reducing mtDNA accumulation and IFN-β secretion, while having the opposite effect in cancer cells.

Massively Concurrent Sub-Cellular Traction Force Videography enabled by Single-Pixel Optical Tracers (SPOTs)

The paper introduces a high-speed, large-field-of-view platform for measuring sub-cellular traction forces in over 10,000 cells at 83 frames per second.

T-cell Repertoire Characteristics of Asymptomatic and Re-detectable Positive COVID-19 Patients

The paper analyzes T-cell receptor repertoires in different phases of COVID-19 to identify immune response patterns and predict recurrent infection risk.

Spatial and temporal plasticity of neoantigen-specific T-cell responses bases on characteristics associated to antigen and TCR

The paper characterizes neoantigen-specific T-cell receptors in a melanoma patient, showing that low-avidity TCRs can provide effective anti-tumor responses and persist long-term in blood and tissues.

Lateral mechanical impedance rather than frontal, promotes cortical expansion of roots

The paper shows that lateral mechanical impedance, not frontal, promotes cortical expansion and radial growth in maize roots.

Elongation index as a sensitive measure of cell deformation in high-throughput microfluidic systems

This paper introduces the Elongation Index (EI) as a new measure for microfluidic deformability cytometry that reduces measurement errors and improves sensitivity to cell mechanical properties.

Phytochromes measure photoperiod in Brachypodium

This study shows that phytochrome C (phyC) in Brachypodium distachyon acts as a molecular timer that communicates night length information to the circadian clock protein ELF3, regulating photoperiodic responses.