Y. Chang

Differential Cerebral White Matter Tract Alterations in Generalized Anxiety Disorder Revealed by Ultra-High Field 7T Diffusion-Weighted Imaging

This study identifies differential white matter tract alterations in generalized anxiety disorder using 7T diffusion imaging, linking them to symptom severity and diagnostic utility.

The Mammalian KU70 C-terminus SAP Domain Is Required to Repair Exogenous DNA Damage

This study shows that the KU70 SAP domain is essential for repairing exogenous DNA damage but not for V(D)J recombination or development.

Multiple Omics Find New Cecal Microbial Features Associated with Feed Efficiency in Ducks

The paper identifies microbial and metabolic differences associated with feed efficiency in ducks using metagenomics, transcriptomics, and metabolomics.

Lipid membrane topographies are regulators for the spatial distribution of liquid protein condensates

This study shows that lipid membrane topography regulates the spatial distribution and shape of liquid protein condensates through capillary forces.

CDK12 Loss Promotes Prostate Cancer Development While Exposing Vulnerabilities to Paralog-Based Synthetic Lethality

This study shows CDK12 loss drives prostate cancer development and identifies CDK13 as a therapeutic target through paralog-based synthetic lethality in CDK12-mutant tumors.

Epstein-Barr Virus Orchestrates Spatial Reorganization and Immunomodulation within the Classic Hodgkin Lymphoma Tumor Microenvironment

This study uses spatial multi-omics to compare EBV-positive and EBV-negative cHL, identifying distinct TME features and immunological signatures linked to EBV.

Development of an orally bioavailable mSWI/SNF ATPase degrader and acquired mechanisms of resistance in prostate cancer

This paper develops an orally bioavailable PROTAC degrader of mSWI/SNF ATPases for prostate cancer and identifies resistance mechanisms through long-term treatment.

Architecture of intact mammalian pyruvate dehydrogenase complex revealed by in-situ structural analysis

This study reveals the in-situ architecture of the mammalian pyruvate dehydrogenase complex using cryo-electron tomography, showing dynamic interactions and variable peripheral compositions.

Structural Basis for Hyperpolarization-dependent Opening of the Human HCN1 Channel

The paper presents cryo-EM structures of human HCN1 in different states to elucidate the structural basis for hyperpolarization-dependent opening of the channel.

mTOR Inhibition Suppresses Salinomycin-Induced Ferroptosis in Breast Cancer Stem Cells by Ironing Out Mitochondrial Dysfunctions

The paper shows that mTOR inhibition reduces Salinomycin-induced ferroptosis in breast cancer stem cells by modulating iron flux and mitochondrial function.

The HP1γ epigenetic silencer dampens IFN-γ response at the gut epithelial barrier

This study identifies HP1γ as an epigenetic repressor of IFN-γ responsive genes at the gut epithelial barrier, showing its role in dampening immune responses.

Genomic deletion of Bcl6 differentially affects conventional dendritic cell subsets and compromises Tfh/Tfr/Th17 cell responses

Anellovirus Structure Reveals a Mechanism for Immune Evasion

This paper determines the structure of an anellovirus, revealing how its unique surface features enable immune evasion by hiding conserved epitopes and exposing diverse ones as decoys.

Divergent evolution of early terrestrial fungi reveals the evolution of Mucormycosis pathogenicity factors

This study investigates the divergent evolution of zygomycete fungi, identifying lineage-specific genomic elements and evolutionary relationships that contribute to Mucormycosis pathogenicity.

On-Demand Fully-Enclosed Superhydrophobic-Optofluidic Device Enabled by High Precision Microstereolithography

This paper introduces a fully-enclosed superhydrophobic optofluidic system with low optical loss, demonstrating its application for CRISPR-labeled quantum dot quantification.

Human anelloviruses produced by recombinant expression of synthetic genomes.

This paper demonstrates the production of human anelloviruses in vitro using synthetic genomes in MOLT-4 cells, showing infectivity in mice and enabling further virology studies.

Divergence of trafficking and polarity mechanisms for PIN auxin transporters during land plant evolution

This study investigates the divergence of PIN auxin transporter trafficking and polarity mechanisms across land plants, revealing differences between bryophytes and flowering plants.

Unlocking the microblogging potential for science and medicine

The paper analyzes Twitter activity of 6,000 biomedical scientists, finding gender differences in tweeting behavior and engagement patterns.

Transcriptome of epibiont Saccharibacteria Nanosynbacter lyticus strain TM7x during establishment of symbiosis

This study examines gene expression changes in Saccharibacteria TM7x and its host during symbiosis establishment, revealing dynamic interactions and functional roles in maintaining the relationship.

Engineering chimeric antigen receptor neutrophils from human pluripotent stem cells for targeted cancer immunotherapy

This study engineers CAR-expressing neutrophils from human pluripotent stem cells, showing enhanced anti-tumor activity against glioblastoma in vitro and in vivo.

Efficient Neutralization of SARS-CoV-2 Omicron and Other VOCs by a Broad Spectrum Antibody 8G3

This study evaluates the neutralization efficacy of antibodies against SARS-CoV-2 Omicron and other variants, finding that antibody 8G3 maintains broad neutralizing activity while EUA antibodies lose effectiveness.

Cohesin mutation sensitizes cancer cells to anti-PD-1 therapy through endogenous retrovirus-mediated PD-L1 upregulation

This study shows cohesin mutations enhance cancer cell sensitivity to anti-PD-1 therapy by increasing PD-L1 through endogenous retrovirus activation.

Experimental and mathematical models of intracellular calcium dynamics for evaluating combined anticancer effects of Afatinib and RP4010 in esophageal cancer

Comprehensive Evaluation of ACE2-Fc Combination with Neutralization Antibody on Broad Protection against SARS-CoV-2 and Its Variants

This study evaluates ACE2-Fc combined with neutralizing antibodies against SARS-CoV-2 variants, showing enhanced neutralization and resistance to escape mutations.

Diverse northern Asian and Jomon-related genetic structure discovered among socially complex Three Kingdoms period Gaya region Koreans

The study reports the first ancient Korean genomes from the Three Kingdoms period, revealing genetic diversity linked to northern Chinese and Japanese Jomon-related ancestry.

Broad ultra-potent neutralization of SARS-CoV-2 variants by monoclonal antibodies specific to the tip of RBD

This paper identifies a monoclonal antibody, 2G1, that neutralizes all SARS-CoV-2 variants with high potency and describes its mechanism of action and therapeutic efficacy in animal models.

Characterization of the flagellar collar reveals structural plasticity essential for spirochete motility

This study characterizes the flagellar collar in Borrelia burgdorferi, revealing its structural plasticity and essential role in spirochete motility through high-resolution in-situ structures.

MEKK3-TGFβ crosstalk regulates inward arterial remodeling

This study identifies endothelial MEKK3 as a regulator of inward arterial remodeling through TGFβ-Smad2/3 signaling, leading to hypertension and atherosclerosis.

Loss of intermediate filament IFB-1 reduces mobility, density and physiological function of mitochondria in C. elegans sensory neurons

This study shows that loss of IFB-1 in C. elegans sensory neurons reduces mitochondrial mobility, density, and physiological function, suggesting a role for neuronal intermediate filaments in mitochondrial transport.

A particle size threshold governs diffusion and segregation of PAR-3 during cell polarization

The paper investigates how PAR-3 oligomer size affects its diffusion and segregation during cell polarization in C. elegans embryos, finding that trimers are essential while larger clusters are not.