F. Fuentes

CD4+ T cells drive corneal nerve damage but not epitheliopathy in an acute aqueous-deficient dry eye model

Elevated glycolytic metabolism of monocytes limits the generation of HIF-1α-driven migratory dendritic cells in tuberculosis

This study shows that elevated glycolytic metabolism in monocytes during tuberculosis impairs their differentiation into migratory dendritic cells, limiting immune response.

Humoral immune responses against seasonal coronaviruses predict efficiency of SARS-CoV-2 spike targeting, FcγR activation, and corresponding COVID-19 disease severity

The paper shows that humoral immune responses against seasonal coronaviruses correlate with SARS-CoV-2 disease severity and antibody targeting of specific epitopes.

Host-derived lipids from tuberculous pleurisy impair macrophage microbicidal-associated metabolic activity

This study shows that host-derived lipids from tuberculous pleurisy reduce glycolytic activity and impair HIF-1-mediated metabolic reprogramming in macrophages, promoting Mtb infection.

Mycobacterium tuberculosis Modulates the Metabolism of Alternatively Activated Macrophages to Promote Foam Cell Formation and Intracellular Survival

This study shows that Mtb modulates macrophage metabolism to promote foam cell formation and survival by altering lipid metabolism and FAO pathways.