M. Ostrowski

mRNA Vaccine-Induced SARS-CoV-2 Spike-Specific IFN-γ and IL-2 T-cell Responses are Predictive of Serological Neutralization and are Transiently Enhanced by Pre-Existing Cross-Reactive Immunity

This study examines how mRNA vaccine-induced T-cell responses correlate with neutralizing antibodies and how pre-existing immunity affects vaccine responses over time.

Immunogenicity of COVID-19 vaccines and their effect on the HIV reservoir in older people with HIV

This study evaluates the immunogenicity of COVID-19 vaccines in older people with HIV and their impact on HIV reservoirs, finding that three doses are needed for optimal neutralizing responses but vaccines may increase HIV reservoirs in those with persistent viremia.

Chemo-sEVs release in cisplatin-resistance ovarian cancer cells are regulated by the lysosomal function

This study shows that cisplatin-resistant ovarian cancer cells release chemo-sEVs regulated by lysosomal function, with RAB27A silencing restoring lysosomal function and reducing sEVs secretion.

Differential global distribution of marine picocyanobacteria gene clusters reveals distinct niche-related adaptive strategies

This study identifies gene clusters in marine picocyanobacteria associated with niche adaptation by analyzing metagenomic and genomic data from different oceanic environments.

Defining marine bacterioplankton community assembly rules by contrasting the importance of environmental determinants and biotic interactions

This study compares how environmental factors and biotic interactions shape bacterioplankton diversity across three oceanographic sites with different environmental conditions and seasonality.

Global phylogeography of marine Synechococcus in coastal areas reveals strikingly different communities than in the open ocean

The paper analyzes global coastal Synechococcus communities using metagenomic data, revealing distinct community structures and niche partitioning compared to open-ocean environments.

Longitudinal Assessment of SARS-CoV-2 Specific T Cell Cytokine-Producing Responses for 1 Year Reveals Persistence of Multi-Cytokine Proliferative Responses, with Greater Immunity Associated with Disease Severity

This study tracks SARS-CoV-2-specific T cell cytokine responses over one year, finding persistent multi-cytokine production with greater immunity linked to disease severity.

A simple protein-based surrogate neutralization assay for SARS-CoV-2

The paper introduces a protein-based assay to detect neutralizing antibodies against SARS-CoV-2, showing it correlates with traditional viral neutralization tests.

Host-derived lipids from tuberculous pleurisy impair macrophage microbicidal-associated metabolic activity

This study shows that host-derived lipids from tuberculous pleurisy reduce glycolytic activity and impair HIF-1-mediated metabolic reprogramming in macrophages, promoting Mtb infection.