Author

C. Cougoule

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 6 Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:host-pathogen & immune response· 7 Organism:human· 4 Organism:bacteria (other)· 2 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Assay:organoid / primary culture· 2

Frequent Co-Authors

E. Meunier· 5 shared R. Planes· 4 shared A. Hessel· 3 shared G. Lugo-Villarino· 3 shared K. Santoni· 3 shared M. Pinilla· 3 shared O. Neyrolles· 3 shared S. Bagayoko· 3 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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5 shared papersImmunology

E. Meunier

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Curcumin-mediated NRF2 induction limits inflammatory damage in preclinical models of cystic fibrosis

S. A. Leon-Icaza, M. Fretaud, S. Cornelie, C. Bureau, L. Yatime, A. R. Floto, S. Renshaw, J.-L. Herrmann, C. Langevin, C. Cougoule, A. Bernut

This study shows curcumin improves inflammation and tissue damage in cystic fibrosis by restoring NRF2 activity in zebrafish and patient-derived airway organoids.

bioRxiv · Mar 17, 2024Immunology

EEF2-inactivating toxins engage the NLRP1 inflammasome and promote epithelial barrier disruption upon Pseudomonas infection

M. Pinilla, R. Mazars, R. Verge, L. Gorse, K. Santoni, K. S. Robinson, G. A. Toh, L. Prouvensier, S. A. Leonicaza, A. Hessel, d. pericat, M. Murris, A. Henras, J. M. Buyck, C. Cougoule, , E. Meunier

This paper shows that Pseudomonas aeruginosa's Exotoxin A activates the NLRP1 inflammasome via EEF2 inactivation, causing epithelial damage and pyroptosis, and identifies ZAK as a key sensor in this process.

bioRxiv · Jan 16, 2023 · PreprintImmunology

Druggable redox pathways against M. abscessus in cystic fibrosis patient-derived airway organoids

S. A. Leon Icaza, S. Bagayoko, R. VERGE, N. Iakobachvili, C. Ferrand, T. Aydogan, C. Bernard, A. Sanchez Dafun, M. Murris-Espin, J. Mazieres, P. J. Bordignon, S. Mazeres, P. Bernes Lasserre, V. Rame, J.-M. Lagarde, , C. Cougoule

This study uses airway organoids to investigate M. abscessus infection in CF patients, showing antioxidant pathways can inhibit bacterial growth and enhance antibiotic efficacy.

bioRxiv · Jan 3, 2022 · PreprintCell Biology

Caspase-1-driven neutrophil pyroptosis promotes an incomplete NETosis upon Pseudomonas aeruginosa infection

K. Santoni, D. Pericat, M. Pinilla, S. Bagayoko, A. Hessel, S. A. Leon-Ycaza, E. Bellard, S. Mazeres, E. Doz-Deblauwe, N. Winter, C. Paget, J.-P. Girard, C. Cougoule, R. Poincloux, M. Lamkanfi, , R. Planes

This study shows that Pseudomonas aeruginosa induces Caspase-1-dependent pyroptosis in neutrophils, leading to incomplete NETosis and promoting bacterial spread.

bioRxiv · Jun 28, 2021 · PreprintImmunology

Phospholipid peroxidation fuels ExoU phospholipase-dependent cell necrosis and supports Pseudomonas aeruginosa-driven pathology

S. Bagayoko, S.-A. Leon-Icaza, M. Pinilla, A. Hessel, K. Santoni, P.-J. Bordignon, F. Moreau, E. Eren, A. Boyance, E. Naser, L. Lefevre, C. Berrone, N. Iacobachvili, A. Metais, Y. Rombouts, , E. Meunier

This study identifies phospholipid peroxidation as a mechanism enhancing ExoU phospholipase activity, leading to cell necrosis and supporting Pseudomonas aeruginosa pathogenesis.

bioRxiv · Feb 17, 2021Immunology

Mycobacterium tuberculosis Modulates the Metabolism of Alternatively Activated Macrophages to Promote Foam Cell Formation and Intracellular Survival

M. Genoula, J. L. Marin Franco, M. Maio, B. Dolotowicz, M. Ferreyra, M. A. Milillo, R. Mascarau, E. J. Morana, D. Palmero, F. Fuentes, B. Lopez, P. Barrionuevo, O. Neyrolles, C. Cougoule, G. Lugo-Villarino, , L. Balboa

This study shows that Mtb modulates macrophage metabolism to promote foam cell formation and survival by altering lipid metabolism and FAO pathways.

bioRxiv · Dec 13, 2019Immunology

Tuberculosis-associated IFN-I induces Siglec-1 on tunneling nanotubes and favors HIV-1 spread in macrophages

C. Verollet, M. Dupont, S. Souriant, L. Balboa, T. Phong, K. Pingris, S. Rousset, C. Cougoule, Y. Romboust, R. Poincloux, M. Ben Neji, C. Allers, D. Kaushal, M. J. Kuroda, S. Benet, , G. Lugo-Villarino

This study identifies Siglec-1 as a factor induced by TB-associated IFN-I that localizes on TNTs and promotes HIV-1 spread in macrophages.

bioRxiv · Nov 12, 2019Cell Biology

Type-3 Secretion System-induced pyroptosis protects Pseudomonas against cell-autonomous immunity

E. Eren, R. Planes, J. M. Buyck, P.-J. Bordignon, A. Colom, O. Cunrath, R. F. Dreier, J. C. Santos, V. Duplan-Eche, E. Näser, A. Peixoto, D. Bumann, C. Cougoule, A. Coste, O. Neyrolles, , E. Meunier

This study shows that Pseudomonas aeruginosa uses its Type-3 Secretion System to induce macrophage pyroptosis, escaping immune trapping, while T3SS-deficient strains are captured by inflammasome-mediated immunity.

bioRxiv · May 28, 2019 · PreprintImmunology