L. Balboa

The immunosuppressive Tuberculosis-associated microenvironment inhibits viral replication and promotes HIV-1 latency in CD4+ T cells

This study shows that the TB-associated microenvironment suppresses HIV-1 replication and promotes latency in CD4+ T cells from HIV-1 patients.

Elevated glycolytic metabolism of monocytes limits the generation of HIF-1α-driven migratory dendritic cells in tuberculosis

This study shows that elevated glycolytic metabolism in monocytes during tuberculosis impairs their differentiation into migratory dendritic cells, limiting immune response.

Tuberculosis-associated IFN-I induces Siglec-1 on tunneling nanotubes and favors HIV-1 spread in macrophages

This study identifies Siglec-1 as a factor induced by TB-associated IFN-I that localizes on TNTs and promotes HIV-1 spread in macrophages.

Host-derived lipids from tuberculous pleurisy impair macrophage microbicidal-associated metabolic activity

This study shows that host-derived lipids from tuberculous pleurisy reduce glycolytic activity and impair HIF-1-mediated metabolic reprogramming in macrophages, promoting Mtb infection.

Mycobacterium tuberculosis Modulates the Metabolism of Alternatively Activated Macrophages to Promote Foam Cell Formation and Intracellular Survival

This study shows that Mtb modulates macrophage metabolism to promote foam cell formation and survival by altering lipid metabolism and FAO pathways.