Author

F. Graeter

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 6

Signature Assays, Organisms & Methods

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Approach:mechanistic / dynamical model· 5 Organism:human· 3 Research Focus:protein folding & dynamics· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:chromatin & epigenetic regulation· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Organism:mouse· 1

Frequent Co-Authors

C. Aponte-Santamaria· 2 shared A. J. Lay· 1 shared A. K. Dasanna· 1 shared A. Kuzhelev· 1 shared A. M. Herrera Rodriguez· 1 shared C. Aponte Santamaria· 1 shared C. Daday· 1 shared D. Butera· 1 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersBiophysics

C. Aponte-Santamaria

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

O-glycans Expand Lubricin and Attenuate its Viscosity and Shear Thinning

S. Boushehri, H. Holey, M. Brosz, P. Gumbsch, L. Pastewka, C. Aponte-Santamaria, F. Graeter

This study uses molecular dynamics simulations to show that O-glycans in lubricin increase its conformational extension, reduce viscosity, but weaken shear thinning at high shear rates.

bioRxiv · Dec 7, 2023 · PreprintBiophysics

DOPA residues endow collagen with radical scavenging capacity

M. Kurth, U. Barayeu, H. Gharibi, A. Kuzhelev, K. Riedmiller, J. Zilke, K. Noack, V. Denysenkov, R. Kappl, T. F. Prisner, R. A. Zubarev, T. P. Dick, F. Graeter

This study identifies DOPA residues in collagen as redox-active components that provide radical scavenging capacity, outperforming their precursors and ascorbic acid.

bioRxiv · Jan 23, 2023Biophysics

Myristoyl's dual role in allosterically regulating and localizing Abl kinase

S. de Buhr, F. Graeter

This study shows myristoyl modulates c-Abl kinase activity by both stabilizing its auto-inhibitory state and promoting membrane localization, which enhances activation through thermodynamic competition.

bioRxiv · Dec 20, 2022Biophysics

The role of hydrodynamic flow in the self-assembly of dragline spider silk proteins

A. M. Herrera Rodriguez, A. K. Dasanna, C. Daday, E. R. Cruz-Chu, C. Aponte Santamaria, U. S. Schwarz, F. Graeter

This study investigates how hydrodynamic flow influences the self-assembly of spider silk proteins through molecular and coarse-grained simulations, revealing flow-induced conformational changes and assembly dynamics.

bioRxiv · Oct 25, 2022 · PreprintBiophysics

Dynamic Disulfide Bond Topologies in von-Willebrand-Factor's C4-Domain Undermine Platelet Binding

F. Kutzki, D. Butera, A. J. Lay, D. M. Maag, J. Chiu, H.-G. Woon, T. Kubar, M. Elstner, C. Aponte-Santamaria, P. Hogg, F. Graeter

This study quantifies disulfide bond topologies in vWF-C4 domain and shows their impact on platelet binding through integrin.

bioRxiv · Aug 20, 2022 · PreprintBiophysics

ATP allosterically stabilizes Integrin-linked kinase for efficient force generation

I. M. Martin, M. M. Nava, S. A. Wickstroem, F. Graeter

This study identifies ATP's role in stabilizing ILK for force generation through molecular dynamics and traction force microscopy.

bioRxiv · Mar 30, 2021Biophysics