H. Gharibi

Deep Plasma Proteome Profiling by Modulating Single Nanoparticle Protein Corona with Small Molecules

This paper demonstrates that adding small molecules to plasma enhances nanoparticle protein corona diversity, significantly increasing the number of detectable proteins in plasma proteome profiling.

Gel-Assisted Proteome Position Integral Shift (GAPPIS) Assay Returns Molecular Weight to Shotgun Proteomics and Identifies Novel Caspase 3 Substrates

The paper introduces GAPPIS, a method to recover molecular weight information from shotgun proteomics, identifying novel caspase 3 substrates in apoptotic cells.

Do light eaters live shorter lives? The case of ultralight Caenorhabditis elegans

This study shows that ultralight Caenorhabditis elegans, grown on isotopically depleted bacteria, have shorter lifespans despite faster growth and maturation.

Multifaceted proteome analysis at solubility, redox, and expression dimensions for target identification

The paper introduces PISA-REX, a high-throughput proteomics method combining redox, expression, and solubility analysis, and demonstrates its application in studying interferon responses in human monocytes and mice.

DOPA residues endow collagen with radical scavenging capacity

This study identifies DOPA residues in collagen as redox-active components that provide radical scavenging capacity, outperforming their precursors and ascorbic acid.

Multi-Omics Analysis of Magnetically Levitated Plasma Biomolecules

The paper uses magnetic levitation to separate plasma biomolecules into ellipsoidal bands and performs multi-omics analysis to identify health-related differences in lipid and metabolite profiles across multiple sclerosis subtypes.

Mapping the GALNT1 substrate landscape with versatile proteomics tools

This study identifies hundreds of novel GALNT1 substrates using proteomics tools, revealing preferences for Thr residues and Pro at positions +3 and +4, and implicating GALNT1 in diverse biological pathways.

Redox regulation of PTPN22 affects the severity of T cell dependent autoimmune inflammation

This study shows that redox regulation of PTPN22 via cysteine 129 affects T cell-dependent autoimmune inflammation severity in mice.

Abnormal (hydroxy)prolines deuterium content redefines hydrogen chemical mass

The paper finds unexpectedly high deuterium levels in proline and hydroxyproline residues of seal bone collagen, challenging assumptions about diet and environmental influences on isotopic signatures.