C. Aponte-Santamaria

This study shows mechanical forces increase VAR2CSA's binding avidity by converting it from monovalent to multivalent through conformational changes exposing additional CSA binding sites.

This study determines the structure of AQP0 tetramers in sphingomyelin/cholesterol membranes and shows how cholesterol stabilizes their arrangement through hydrophobic interactions and avidity effects.

This study investigates how photoresists interact with lipid membranes using simulations and assays, finding permeability varies widely and is influenced by membrane properties.

This study uses Brownian dynamics simulations to investigate how shear flow affects VWF chain adsorption, aggregation, and extension, revealing their interplay in hemostasis.

This study quantifies disulfide bond topologies in vWF-C4 domain and shows their impact on platelet binding through integrin.

This study identifies an allosteric network in vinculin regulated by talin, showing how force and binding dynamics control focal adhesion formation.

This study investigates how mutations G1324A and G1324S in the vWF A1 domain affect its thermodynamic stability and conformational flexibility, leading to reduced platelet adhesion in type 2M von Willebrand disease.