Ageing compromises mouse thymus function and remodels epithelial cell differentiation
C. P. Ponting, J. Baran-Gale, M. D. Morgan, S. Maio, F. Dhalla, I. Calvo-Asensio, M. Deadman, A. E. Handel, A. Maynard, S. Chen, F. Green, R. Sit, N. Neff, S. Darmanis, W. Tan, , G. A. Holländer
This study investigates how ageing affects mouse thymus function, revealing that progenitor cell differentiation is disrupted, leading to impaired T cell selection and self-antigen representation.
bioRxiv · Mar 2, 2020Immunology