Author

F. Dhalla

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 5 Organism:mouse· 5 Approach:experimental assay· 4 Assay:scRNA-seq· 3 Research Focus:clustering· 2 Research Focus:differential expression· 2 Organism:human· 2 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

S. Maio· 5 shared A. E. Handel· 3 shared M. E. Deadman· 3 shared A. White· 2 shared F. Klein· 2 shared G. A. Hollander· 2 shared G. Anderson· 2 shared I. Calvo-Asensio· 2 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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5 shared papersImmunology

S. Maio

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5 papers

Recent·Most cited

Combined multidimensional single-cell protein and RNA profiling dissects the cellular and functional heterogeneity of thymic epithelial cells

F. Klein, C. Veiga-Villauriz, A. Boersch, S. Maio, S. Palmer, S. Zuklys, I. Calvo-Asensio, L. Musette, M. E. Deadman, F. Dhalla, A. White, B. Lucas, G. Anderson, G. A. Hollaender

The paper uses combined single-cell protein and RNA profiling to identify and characterize novel subpopulations of thymic epithelial cells and their functional roles.

bioRxiv · Sep 14, 2022Immunology

Developmental dynamics of the neural crest-mesenchymal axis in creating the thymic microenvironment

A. E. Handel, S. Cheuk, F. Dhalla, S. Maio, T. Hubscher, I. Rota, M. E. Deadman, O. Ekwall, M. Lutolf, K. Weinberg, G. Hollander

The paper uses single-cell profiling to analyze the dynamic changes in non-epithelial thymic stroma across development, identifying novel fibroblast subtypes and their roles in thymus organogenesis.

bioRxiv · Nov 8, 2021Immunology

A FOXN1 mutation competitively displaces wild-type FOXN1 from higher order nuclear condensates to cause immunodeficiency

I. A. Rota, A. E. Handel, F. Klein, S. Maio, F. Dhalla, M. E. Deadman, S. Cheuk, J. A. Newman, Y. S. Michaels, S. Zuklys, N. Prevot, P. Hublitz, P. D. Charles, A. S. Gkazi, E. Adamopoulou, , G. A. Hollander

This paper identifies a FOXN1 mutation that displaces wild-type FOXN1 from nuclear condensates, leading to immunodeficiency and athymia in heterozygotes.

bioRxiv · Mar 28, 2021 · PreprintImmunology

Ageing compromises mouse thymus function and remodels epithelial cell differentiation

C. P. Ponting, J. Baran-Gale, M. D. Morgan, S. Maio, F. Dhalla, I. Calvo-Asensio, M. Deadman, A. E. Handel, A. Maynard, S. Chen, F. Green, R. Sit, N. Neff, S. Darmanis, W. Tan, , G. A. Holländer

This study investigates how ageing affects mouse thymus function, revealing that progenitor cell differentiation is disrupted, leading to impaired T cell selection and self-antigen representation.

bioRxiv · Mar 2, 2020Immunology

Biologically indeterminate yet ordered promiscuous gene expression in single medullary thymic epithelial cells

F. Dhalla, J. Baran-Gale, S. Maio, L. Chappell, G. A. Hollander, C. Ponting

The paper analyzes single mTEC transcriptomes to determine if promiscuous gene expression is stochastic or coordinated, finding it is ordered yet biologically indeterminate.

bioRxiv · Feb 19, 2019Immunology