Cancer BiologybioRxivPreprint
IRF4 deficiency vulnerates B cell progeny for leukemogenesis via somatically acquired Jak3 mutations conferring IL-7 hypersensitivity
D. Das Gupta, C. Paul, N. Samel…·M. Lohoff
This study shows IRF4 deficiency leads to B cell leukemia via Jak3 mutations that increase IL-7 sensitivity, and JAK inhibition improves survival in a mouse model.
DOI 10.1101/2022.02.16.480573