Dynamics and quantitative contribution of the aminoglycoside 6'-N-acetyltransferase type Ib to amikacin resistance
O. d'Udekem d'Acoz, F. Hue, T. Ye, L. Wang, M. Leroux, L. Rajngewerc, T. Tran, K. Phan, M. S. Ramirez, W. Reisner, M. Tolmasky, R. Reyes Lamothe
This paper quantifies the relationship between AAC(6')-Ib enzyme concentration and amikacin resistance in E. coli, showing a linear increase until a plateau due to protein aggregation.
bioRxiv · Sep 5, 2023 · PreprintMicrobiology