M. S. Ramirez

Structure-activity relationship of pyrrolidine pentamine derivatives as inhibitors of the aminoglycoside 6'-N-acetyltransferase type Ib

This study identifies pyrrolidine pentamine derivatives as inhibitors of AAC(6')-Ib, showing that structural modifications affect inhibitory activity and that molecular docking correlates with potency.

Hetero-antagonism of avibactam and sulbactam with cefiderocol in carbapenem-resistant Acinetobacter spp.

This study investigates the molecular mechanisms of cefiderocol resistance and antagonism with avibactam and sulbactam in carbapenem-resistant Acinetobacter strains.

Dynamics and quantitative contribution of the aminoglycoside 6'-N-acetyltransferase type Ib to amikacin resistance

This paper quantifies the relationship between AAC(6')-Ib enzyme concentration and amikacin resistance in E. coli, showing a linear increase until a plateau due to protein aggregation.

Fever like temperature impacts on Staphylococcus aureus and Pseudomonas aeruginosa interaction, physiology, and virulence both in vitro and in vivo

This study examines how fever-like temperatures (39°C) affect the interaction, physiology, and virulence of Staphylococcus aureus and Pseudomonas aeruginosa in vitro and in vivo.

The Iron Content of Human Serum Albumin Modulates the Susceptibility of Acinetobacter baumannii to Cefiderocol

This paper shows that human serum albumin (HSA) increases Acinetobacter baumannii resistance to cefiderocol by modulating iron uptake and beta-lactam resistance gene expression.

Amikacin potentiator activity of zinc complexed to a pyrithione derivative with enhanced solubility

This paper tests a zinc-pyrithione derivative with improved solubility as an amikacin potentiator against antibiotic-resistant bacteria.

Impact of Human Serum Proteins on Susceptibility of Acinetobacter baumannii to Cefiderocol: role of iron transport

The paper shows that human serum and its components increase Acinetobacter baumannii resistance to cefiderocol by altering iron uptake and beta-lactam resistance genes.

Interplay between meropenem and human serum albumin on expression of carbapenem resistance genes and natural competence in Acinetobacter baumannii

This study shows that human serum albumin and meropenem together enhance natural transformation and gene expression in Acinetobacter baumannii, potentially promoting resistance and evolution.

Cerebrospinal fluid (CSF) boosts metabolism and virulence expression factors in Acinetobacter baumannii

This study shows that cerebrospinal fluid (CSF) enhances virulence factor expression and metabolic processes in low-virulence Acinetobacter baumannii strains.

The H-NS regulator plays a role in the stress induced by carbapenemase expression in Acinetobacter baumannii

This study shows H-NS alleviates envelope stress from MBL expression and DNA-damaging agents in A. baumannii, linking it to stress response and carbapenem resistance.

Restoration of Susceptibility to Amikacin by 8-Hydroxyquinoline Analogs Complexed to Zinc

This study evaluates 8-hydroxyquinoline analogs complexed with zinc to restore amikacin susceptibility in AAC(6)-Ib-producing Acinetobacter baumannii strains.

Interspecies DNA acquisition by a naturally competent Acinetobacter baumannii strain

This study shows that natural transformation enables Acinetobacter baumannii to acquire antibiotic resistance genes from Klebsiella pneumoniae, contributing to the emergence of multi-drug-resistant strains.