Author

M. LeRoux

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:E. coli· 4 Research Focus:host-pathogen & immune response· 3 Organism:bacteria (other)· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Assay:DNA methylation· 1

Frequent Co-Authors

M. T. Laub· 3 shared M. L. Littlehale· 2 shared S. Srikant· 2 shared A. Cepauskas· 1 shared A. Garcia-Pino· 1 shared A. Johannesman· 1 shared A. Leung· 1 shared A. Talavera· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersMicrobiology

M. T. Laub

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6 papers

Recent·Most cited

Phages carry orphan antitoxin-like enzymes to neutralize the DarTG1 toxin-antitoxin defense system

A. Johannesman, N. A. Carlson, M. LeRoux

The paper identifies an orphan antitoxin-like enzyme in phages that neutralizes the bacterial DarTG1 toxin-antitoxin defense system by removing ADP-ribose modifications from phage DNA.

bioRxiv · Jul 11, 2024Microbiology

Dynamics and quantitative contribution of the aminoglycoside 6'-N-acetyltransferase type Ib to amikacin resistance

O. d'Udekem d'Acoz, F. Hue, T. Ye, L. Wang, M. Leroux, L. Rajngewerc, T. Tran, K. Phan, M. S. Ramirez, W. Reisner, M. Tolmasky, R. Reyes Lamothe

This paper quantifies the relationship between AAC(6')-Ib enzyme concentration and amikacin resistance in E. coli, showing a linear increase until a plateau due to protein aggregation.

bioRxiv · Sep 5, 2023 · PreprintMicrobiology

Direct activation of an innate immune system in bacteria by a viral capsid protein

T. Zhang, H. Tamman, K. Coppieters't Wallant, T. Kurata, M. LeRoux, S. Srikant, T. Brodiazhenko, A. Cepauskas, A. Talavera, C. Martens, G. C. Atkinson, V. Hauryliuk, A. Garcia-Pino, M. T. Laub

This study identifies a bacterial immune system that directly senses a viral capsid protein through a toxin-antitoxin system, revealing a PAMP-like mechanism for innate immunity in bacteria.

bioRxiv · May 30, 2022 · PreprintMicrobiology

The DarTG toxin-antitoxin system provides phage defense by ADP-ribosylating viral DNA

M. LeRoux, S. Srikant, M. L. Littlehale, G. Teodoro, S. Doron, M. Badiee, A. Leung, R. Sorek, M. T. Laub

This study identifies DarTG toxin-antitoxin systems in E. coli that defend against phage by ADP-ribosylating viral DNA, with phages evolving resistance through DNA polymerase or anti-DarT factors.

bioRxiv · Sep 27, 2021 · PreprintMicrobiology

Low cost and sustainable hyaluronic acid production in a manufacturing platform based on Bacillus subtilis 3NA strain

S. Cerminati, M. Leroux, P. Anselmi, S. Peiru, J. C. Alonso, B. Priem, H. G. Menzella

This paper designs a low-cost, sustainable platform for hyaluronic acid production using Bacillus subtilis 3NA, achieving high profitability and environmental benefits.

bioRxiv · Jan 18, 2021Bioengineering

Stress induces the transcription of toxin-antitoxin systems but does not activate toxin

M. LeRoux, P. Culviner, Y. J. Liu, M. L. Littlehale, M. T. Laub

The paper shows stress increases TA system transcription but does not release toxin, suggesting TA systems may not promote stress survival.

bioRxiv · Mar 2, 2020 · PreprintMicrobiology