F. Islam

Unveiling the Holliday junction conformational dynamics upon binding with architectural proteins IHF

This study investigates how IHF variants bind and stabilize the open conformation of Holliday junctions.

Evolutionary analysis of Quinone Reductases 1 and 2 suggest that NQO2 evolved to function as a pseudoenzyme

This study shows NQO2 evolved to have low catalytic efficiency with NADH, while NQO1 evolved high efficiency, suggesting functional divergence between the two enzymes.

Tonic IKK signalling regulates naive T cell survival in vivo by both repressing RIPK1 dependent extrinsic cell death pathways and independent activation of NF-κB

Probing the molecular mechanism of action of Deinococcus radiodurans RecD2 at single-molecule resolution

This study investigates the DNA unwinding dynamics of DrRecD2 using single-molecule techniques, revealing its binding preference and ATP-dependent unwinding behavior.

BANCOVID, the first D614G variant mRNA-based vaccine candidate against SARS-CoV-2 elicits neutralizing antibody and balanced cellular immune response

This paper develops and characterizes an mRNA-LNP vaccine candidate targeting the D614G variant of SARS-CoV-2, showing neutralizing antibody and balanced cellular immune responses in preclinical trials.