A partnership of the lipid scramblase XK and of the lipid transfer protein VPS13A at the plasma membrane
A. Guillen-Samander, Y. Wu, S. S. Pineda, F. J. Garcia, J. N. Eisen, M. Leonzino, B. Ugur, M. Kellis, M. Heiman, P. De Camilli
This study shows that VPS13A and XK interact at ER-PM contacts, with VPS13A's PH domain binding XK, and suggests this interaction may link lipid transfer to PM lipid scrambling, potentially contributing to neurodegeneration.
bioRxiv · Mar 30, 2022Cell Biology