P. De Camilli

Lysosome damage triggers acute formation of ER to lysosomes membrane tethers mediated by the bridge-like lipid transport protein VPS13C

The paper shows that VPS13C senses lysosome damage, relocates to lysosomes, and tethers them to the ER, suggesting a protective lipid transport response.

Ectopic Reconstitution of a Spine-Apparatus Like Structure Provides Insight into Mechanisms Underlying Its Formation

The paper shows that expressing a synaptopodin construct in non-neuronal cells generates ER stacks resembling the spine apparatus, revealing a role for synaptopodin-dependent actin matrix in their formation.

VPS13B is localized at the cis-trans Golgi complex interface and is a functional partner of FAM177A1

This study identifies VPS13B's localization at the cis-trans Golgi interface and shows its functional interaction with FAM177A1 in lipid transport and Golgi dynamics.

A complex of the lipid transport ER proteins TMEM24 and C2CD2 with band 4.1 at cell-cell contacts

The paper identifies a complex of TMEM24 and C2CD2 with band 4.1 proteins at ER/PM junctions, showing their role in lipid transport and cell-cell contact regulation.

Erythroid differentiation dependent interaction of VPS13A with XK at the plasma membrane of K562 cells

The paper investigates the interaction of VPS13A with XK at ER-PM contacts in K562 cells during erythroid differentiation, showing it requires a permissive state dependent on cell type and functional state.

End Binding protein 1 promotes specific motor-cargo association in the cell body prior to axonal delivery of Dense Core Vesicles

This study identifies EBP-1's role in promoting specific kinesin-3/DCV association in C. elegans neurons, revealing a mechanism for motor-cargo specificity in axonal transport.

ATG9 vesicles comprise the seed membrane of mammalian autophagosomes

This study identifies ATG9 vesicles as the seed membrane for mammalian autophagosomes, showing they integrate proteins like LC3-II and are diluted as autophagosomes expand.

Membrane remodeling properties of the Parkinson's disease protein LRRK2

This study shows that LRRK2 binds and remodels lipid membranes, suggesting its role in membrane dynamics and signaling.

A partnership of the lipid scramblase XK and of the lipid transfer protein VPS13A at the plasma membrane

This study shows that VPS13A and XK interact at ER-PM contacts, with VPS13A's PH domain binding XK, and suggests this interaction may link lipid transfer to PM lipid scrambling, potentially contributing to neurodegeneration.

In situ architecture of the lipid transport protein VPS13C at ER-lysosomes membrane contacts

The paper presents the first in situ evidence for a bridge-like structure of VPS13C at ER-lysosome contacts, supporting its role in lipid transport.

SHIP164 is a Chorein Motif Containing Lipid Transport Protein that Controls Membrane Dynamics and Traffic at the Endosome-Golgi Interface.

This study identifies SHIP164 as a lipid transport protein that facilitates bulk lipid transfer at the endosome-Golgi interface, affecting membrane traffic and organelle movement.

ER-lysosome lipid transfer protein VPS13C/PARK23 prevents aberrant mtDNA-dependent STING signaling

The paper shows that VPS13C deficiency leads to lysosomal lipid changes and activates the cGAS/STING pathway via mtDNA accumulation and impaired STING degradation.

VPS13D bridges the ER to Miro containing membranes

The paper shows VPS13D bridges ER and Miro-containing membranes to facilitate lipid transport between ER and mitochondria, linking yeast and metazoan functions of Gem1/Miro.

Optimized Vivid-derived Magnets photodimerizers for subcellular optogenetics

This paper describes the development of enhanced Magnets (eMags) for optogenetic control of subcellular processes without requiring concatemerization or low-temperature preincubation.

JIP3 links lysosome transport to regulation of multiple components of the axonal cytoskeleton

This study shows that JIP3 depletion disrupts axonal cytoskeleton organization and causes lysosome accumulations in human neurons, linking lysosome transport to cytoskeletal regulation.

Overlapping roles of JIP3 and JIP4 in promoting axonal transport of lysosomes in human iPSC-derived neurons

This study investigates the roles of JIP3 and JIP4 in axonal lysosome transport using human iPSC-derived neurons, showing their involvement in preventing lysosome accumulation and amyloid-beta production.

Lowe Syndrome-linked endocytic adaptors direct membrane cycling kinetics with OCRL in Dictyostelium discoideum.

This study identifies F&H peptide-containing proteins that interact with OCRL/Dd5P4 in Dictyostelium discoideum, revealing their role in endocytic membrane cycling and potential involvement in Lowe Syndrome phenotypes.

Nanoscale subcellular architecture revealed by multicolor 3D salvaged fluorescence imaging

This paper introduces a super-resolution microscope that images whole mammalian cells at ~20 nm 3D resolution, revealing complex cellular structures previously only visible via electron microscopy.

A programmable DNA-origami platform for studying protein-mediated lipid transfer between bilayers

This study uses DNA-origami structures to measure lipid transfer distances mediated by the SMP domain of E-Syt1, supporting a shuttle model over a distance exceeding the SMP dimer length.

Single-molecule force spectroscopy of protein-membrane interactions

The paper quantifies protein-membrane interactions using single-molecule force spectroscopy, showing C2 domains resist forces of 2-7 pN and have binding energies of 4-14 kBT.