Improved synthesis and application of an alkyne-functionalized isoprenoid analogue to study the prenylomes of motor neurons, astrocytes and their stem cell progenitors
K. Suazo, V. Mishra, S. Maity, S. Auger, K. Justyna, A. Petre, L. Ottoboni, J. Ongaro, S. Corti, F. Lotti, S. Przedborski, M. D. Distefano
The paper improves the synthesis of C15AlkOPP and uses it to label and analyze prenylated proteins in motor neurons, astrocytes, and their stem cell progenitors, identifying 54, 50, and 84 prenylated proteins respectively.
bioRxiv · Mar 3, 2024Biochemistry