Hypoxia shapes the immune landscape in lung injury promoting inflammation persistence
A. S. Mirchandani, S. J. Jenkins, C. C. Bain, H. Lawson, P. Coelho, F. Murphy, D. Griffith, A. Zhang, M. A. Sanchez-Garcia, L. Reyes, T. Morrison, S. Arienti, P. Sadiku, E. Watts, R. Dickinson, , S. Walmsley
This study shows hypoxia suppresses type I interferon signaling in ALI, leading to monocytopenia and unchecked inflammation, which can be mitigated by CSF1 administration.
bioRxiv · Mar 11, 2022 · PreprintCell Biology