S. Taylor

High Shear Stress Reduces ERG Causing Endothelial-Mesenchymal Transition and Pulmonary Arterial Hypertension

The paper shows high shear stress induces endothelial-mesenchymal transition and pulmonary arterial hypertension by reducing ERG expression, which can be mitigated by ERG replenishment.

High resolution mapping of the breast cancer tumor microenvironment using integrated single cell, spatial and in situ analysis of FFPE tissue

This paper integrates single cell, spatial, and in situ technologies to analyze FFPE breast cancer tissue, revealing molecular insights into tumor subtypes and progression.

Byproducts of inflammatory radical metabolism provide transient nutrient niches for microbes in the inflamed gut

The paper investigates how inflammatory radicals generate tartaric acid isomers, which serve as transient nutrients for gut pathogens in murine models.

Cytokine-expression patterns reveal coordinated immunological programs associated with persistent MRSA bacteremia

This study uses tensor-based integration of host transcriptional and proteomic data to identify immunological patterns associated with persistent MRSA bacteremia outcomes.

Proximity labelling identifies pro-migratory endocytic recycling cargo and machinery of the Rab4 and Rab11 families

The paper uses proximity labeling to identify protein complexes associated with Rab4, Rab11a, and Rab25 in cancer cells, revealing their roles in endocytic recycling and cell migration.

Systematic analysis of YFP gene traps reveals common discordance between mRNA and protein across the nervous system

The paper systematically analyzes YFP gene traps in Drosophila to show widespread discordance between mRNA and protein expression in the nervous system, revealing common post-transcriptional regulation.

Endogenous Retroviral Elements Generate Pathologic Neutrophils and Elastase Rich Exosomes in Pulmonary Arterial Hypertension

The paper shows that endogenous retroviruses contribute to neutrophil dysfunction and exosome-mediated pulmonary arterial hypertension.

Multi-omic profiling reveals widespread dysregulation of innate immunity and hematopoiesis in COVID-19

Single-cell multi-omic profiling identifies immune dysregulation in severe COVID-19, including neutrophil hyperactivation and anti-inflammatory monocytes.

PARG inhibition induces replication catastrophe in ovarian cancer cells with down-regulated DNA replication genes

This study shows that PARG inhibition causes replication catastrophe in some ovarian cancer cells with down-regulated DNA replication genes, suggesting a potential biomarker for PARG inhibitor response.

Type-1 IFN primed monocytes in pathogenesis of idiopathic pulmonary fibrosis

The paper identifies type-1 IFN-primed monocytes as key drivers of fibrosis in IPF, showing their increased levels, altered phenotype, and potential as therapeutic targets.

The in situ structure of Parkinson’s disease-linked LRRK2

This study uses cryo-electron tomography to reveal the in situ structure of LRRK2 with a pathogenic mutation, showing its oligomerization around microtubules and functional domains.

Structures of the PKA RIα holoenzyme with the FLHCC driver J-PKAcα or wild type PKAcα

This paper reports the crystal structures of J-PKAc fusion and wild-type PKA holoenzymes, revealing structural differences and conformational dynamics that may impact their function in FLHCC.

LOW-BIAS RNA SEQUENCING OF THE HIV-2 GENOME FROM BLOOD PLASMA

This study uses RNA-Seq without PCR amplification to sequence the HIV-2 genome from plasma samples, revealing low genetic diversity in the vpx gene.

A Data Citation Roadmap for Scientific Publishers

This paper provides a roadmap for scientific publishers to implement data citation following the JDDCP principles, guiding authors and publishers through the lifecycle of a paper.

Forecasting biodiversity in breeding birds using best practices

This study evaluates biodiversity forecasts for breeding birds using best practices, finding that no model consistently outperformed a baseline constant richness model.