Chemokine positioning determines mutually exclusive roles for their receptors in extravasation of pathogenic human T cells
F. Parween, S. P. Singh, H. H. Zhang, N. Kathuria, F. A. Otaizo-Carrasquero, A. Shamsaddini, P. J. Gardina, S. Ganesan, J. Kabat, H. A. Lorenzi, T. G. Myers, J. M. Farber
This study identifies that chemokine receptors on pathogenic human T cells have mutually exclusive roles in extravasation, with CCR6 mediating arrest and CCR2 enabling transendothelial migration through distinct ligand interactions.
bioRxiv · Jan 25, 2023 · PreprintImmunology