Author

F. Singh

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Organism:mouse· 3 Research Focus:cell signaling & trafficking· 2 Assay:proteomics· 2 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. R. Prescott· 3 shared I. Ganley· 2 shared A. G. Love· 1 shared A. Ordureau· 1 shared A. Reith· 1 shared E. Barini· 1 shared G. Ball· 1 shared I. G. Ganley· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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3 shared papersCell Biology

A. R. Prescott

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

PINK1 regulated mitophagy is evident in skeletal muscles

F. Singh, L. P. Wilhelm, A. R. Prescott, K. Ostacolo, J.-F. Zhao, M. H. Ogmundsdottir, I. G. Ganley

The paper shows that PINK1 loss reduces mitophagy in skeletal muscle, which is restored by a POLGD257A mutation, highlighting skeletal muscle as a model for studying PINK1-dependent mitophagy.

bioRxiv · Nov 9, 2023 · PreprintCell Biology

Global ubiquitylation analysis of mitochondria in primary neurons identifies physiological Parkin targets following activation of PINK1

O. Antico, A. Ordureau, M. Stevens, F. Singh, M. Gierlinski, E. Barini, M. Rickwood, A. R. Prescott, R. Toth, I. Ganley, W. Harper, M. Muqit

The paper identifies 49 PINK1-dependent ubiquitylated proteins in mouse neurons and develops a resource to visualize mitochondrial ubiquitin sites.

bioRxiv · Apr 1, 2021Biochemistry

Pharmacological rescue of impaired mitophagy in Parkinson's disease-related LRRK2 G2019S knock-in mice

F. Singh, A. R. Prescott, G. Ball, A. Reith, I. Ganley

This study shows that the LRRK2 G2019S mutation impairs mitophagy in mice, and that LRRK2 inhibitors can rescue this defect, suggesting a potential therapy for Parkinson's disease.

bioRxiv · Dec 7, 2020Cell Biology

Comprehensive proteomics analyses identify PIM kinases as key regulators of IL-15 driven activation of intestinal intraepithelial lymphocytes

O. J. James, M. Vandereyken, J. M. Marchingo, F. Singh, A. G. Love, M. Swamy

The paper uses proteomics to identify PIM kinases as critical regulators of IL-15-driven activation in intestinal intraepithelial lymphocytes, linking them to Coeliac disease.

bioRxiv · Mar 27, 2020Immunology