Author

I. G. Ganley

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

L. P. Wilhelm· 2 shared A. Keenlyside· 1 shared A. R. Prescott· 1 shared A. Rousseau· 1 shared F. Singh· 1 shared G. Becchi· 1 shared G. Masson· 1 shared I. Volpi· 1 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCell Biology

L. P. Wilhelm

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2 papers

Recent·Most cited

Cell BiologybioRxivPreprintNov 9, 2023

PINK1 regulated mitophagy is evident in skeletal muscles

F. Singh, L. P. Wilhelm, A. R. Prescott…·I. G. Ganley

The paper shows that PINK1 loss reduces mitophagy in skeletal muscle, which is restored by a POLGD257A mutation, highlighting skeletal muscle as a model for studying PINK1-dependent mitophagy.

DOI 10.1101/2023.11.09.566402

mouseexperimental assay

𝕏 PostBluesky

BiochemistrybioRxivMar 20, 2023

Kinome screening identifies integrated stress response kinase EIF2AK1 / HRI as a negative regulator of PINK1 mitophagy signaling

P. Singh, S. Agarwal, I. Volpi…·M. M. K. Muqit

The paper identifies EIF2AK1/HRI as a negative regulator of PINK1 mitophagy signaling through siRNA screening and pharmacological inhibition.

DOI 10.1126/sciadv.adn2528

humanbulk RNA-seq

𝕏 PostBluesky