Loss of mutant TP53 does not impair the sustained proliferation, survival ormetastasis of diverse cancer cells
Z. Wang, F. Vailllant, C. Chang, C. Riffkin, E. Lieschke, S. Diepstraten, D. Huang, J. E. Visvader, M. J. Herold, G. Kelly, A. Strasser
This study shows that removing mutant TP53 does not affect cancer cell survival, proliferation, or metastasis, suggesting GOF effects are not universally required for malignant growth.
bioRxiv · Mar 30, 2020 · PreprintCancer Biology