A. Strasser

Early cytokine-driven adaptation of survival pathways in lymphoid cells during targeted therapies

This study shows that CLL cells rapidly adapt to venetoclax by upregulating pro-survival proteins and cytokines, suggesting combination therapies targeting these pathways could improve treatment outcomes.

Combined absence of TRP53 target genes ZMAT3, PUMA and p21 cause a high incidence of cancer in mice

The paper shows that combined absence of TRP53 target genes ZMAT3, PUMA, and p21 in mice leads to a higher incidence of cancer, with different tumor types depending on which genes are missing.

Relative importance of MCL-1's Anti-Apoptotic versus Non-Apoptotic Functions in vivo

This study replaces MCL-1 with other anti-apoptotic proteins in mice to determine the relative importance of MCL-1's anti-apoptotic versus non-apoptotic functions in development and physiology.

Deletion of the transcriptional regulator TFAP4 accelerates c-MYC-driven lymphomagenesis

This study shows that deleting TFAP4 in E-MYC transgenic mice accelerates lymphoma development by blocking B cell differentiation.

Genome-wide in vivo CRISPR screens identify GATOR1 as a potent tumor suppressor in MYC-driven lymphomagenesis

The paper identifies GATOR1 as a tumor suppressor in MYC-driven lymphomagenesis using in vivo CRISPR screens and shows its sensitivity to mTOR inhibitors.

BCL-XL is essential for the protection from secondary anemia caused by radiation-induced fatal kidney damage

The paper shows that BCL-XL protects adult kidneys from radiation-induced damage, leading to secondary anemia, and highlights its importance in cancer therapy combinations.

Loss of mutant TP53 does not impair the sustained proliferation, survival ormetastasis of diverse cancer cells

This study shows that removing mutant TP53 does not affect cancer cell survival, proliferation, or metastasis, suggesting GOF effects are not universally required for malignant growth.

Humanized Mcl-1 mice enable accurate pre-clinical evaluation of MCL-1 inhibitors destined for clinical use

This study develops a humanized Mcl-1 mouse model to evaluate MCL-1 inhibitors, showing improved sensitivity to S63845 and effective tumor remission in pre-clinical trials.

miR17~92 is essential for the survival of hematopoietic stem and progenitor cells by restraining pro-apoptotic BIM

This study shows that miR17~92 is essential for hematopoietic stem and progenitor cell survival by suppressing the pro-apoptotic protein BIM.