M. J. Herold

This study replaces MCL-1 with other anti-apoptotic proteins in mice to determine the relative importance of MCL-1's anti-apoptotic versus non-apoptotic functions in development and physiology.

The paper identifies GATOR1 as a tumor suppressor in MYC-driven lymphomagenesis using in vivo CRISPR screens and shows its sensitivity to mTOR inhibitors.

This study shows that IL-1β is ubiquitylated and degraded to limit its inflammatory activity, with specific ubiquitin modifications and electrostatic interactions playing key roles.

This study shows that removing mutant TP53 does not affect cancer cell survival, proliferation, or metastasis, suggesting GOF effects are not universally required for malignant growth.

This study identifies Erg as a critical transcription factor initiating B-lymphopoiesis by regulating gene networks essential for B-cell development and V(D)J recombination.

This study develops a humanized Mcl-1 mouse model to evaluate MCL-1 inhibitors, showing improved sensitivity to S63845 and effective tumor remission in pre-clinical trials.

This study shows that miR17~92 is essential for hematopoietic stem and progenitor cell survival by suppressing the pro-apoptotic protein BIM.