Targeting IDH1-Mutated Oligodendroglioma with Acid Ceramidase Inhibitors
H. Muley Vilamu, T. Dowdy, F. Zaibaq, G. Karadimov, A. Li, H. Song, M. Zhang, W. Zhang, Z. Wong, L. Zhang, A. Lita, M. Larion
This study shows that inhibiting acid ceramidase (AC) induces apoptosis and improves survival in IDH1-mutated oligodendroglioma by increasing ceramide levels and activating both extrinsic and intrinsic apoptosis pathways.
bioRxiv · Apr 27, 2024 · PreprintCancer Biology