Molecular BiologyMolecular TherapyPeer-reviewed
Structural basis of liver de-targeting and neuronal tropism of CNS-targeted AAV capsids
Tyler J. Brittain, Seongmin Jang, Gerard Michael Coughlin…·Viviana Gradinaru
The paper solves cryo-EM structures of AAV capsids and their complexes with AAVR to design variants with reduced liver targeting and altered brain cell tropism.
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