Timothy F. Shay

This study shows that Hrs, an ESCRT-0 protein, modulates AMPA receptor currents and Ca2+-dependent signaling by sensing and responding to neuronal activity at synapses.

The paper uses Perturb-seq in mice to identify genes that promote collateral artery formation by comparing gene expression between guinea pigs and mice.

The paper solves cryo-EM structures of AAV capsids and their complexes with AAVR to design variants with reduced liver targeting and altered brain cell tropism.

This paper introduces GEMINI, a tool that records cellular activity histories with high temporal resolution, and demonstrates its application in tracking transcriptional changes and inflammation dynamics in vivo.

This study demonstrates that systemic AAV delivery enables widespread calcium indicator expression in marmosets, allowing functional optical imaging of visual area MT at multiple scales.

This study engineers AAVs targeting human carbonic anhydrase IV to enhance brain gene delivery, finding that optimized variants achieve 100-fold greater transduction than AAV9.

This paper identifies AAV serotypes effective for transducing amphibian CNS cells and develops tools for neural circuit tracing and manipulation in multiple amphibian species.