Jonathan D. Hoang

This study shows that spinal nociceptive denervation reduces autonomic remodeling and ventricular arrhythmias after myocardial infarction in male swine.

The paper solves cryo-EM structures of AAV capsids and their complexes with AAVR to design variants with reduced liver targeting and altered brain cell tropism.

This study engineers AAVs targeting human carbonic anhydrase IV to enhance brain gene delivery, finding that optimized variants achieve 100-fold greater transduction than AAV9.

This study shows that the gut microbiome increases mitochondrial respiration and oxidative stress in the brain of a Parkinson's disease mouse model, worsening motor symptoms.

The paper introduces a programmable self-assembling protein system to model intracellular protein aggregation in neurodegenerative diseases and reveals disease-specific aggregate-organelle interactions.

This study investigates the anti-arrhythmic effects of thoracic epidural blockade after myocardial infarction, finding it reduces ventricular tachyarrhythmia inducibility and improves parasympathetic function.