BiochemistrybioRxiv
Unique structural features govern the activity of a human mitochondrial AAA+ disaggregase, Skd3.
R. R. Cupo, A. Rizo, G. A. Braun…·J. Shorter
The paper reports the structure of Skd3-substrate complex, revealing its dodecamer formation and mechanism of protein disaggregation, with implications for SCN and MGCA7.
DOI 10.1016/j.celrep.2022.111408